gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR T cells bind the tumor-associated surface antigen and, upon CAR signaling, directly kill antigen-positive cells via perforin/granzyme-mediated cytolysis and apoptosis (e.g., Fas/FasL).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CAR-mediated recognition; TCR-independent signaling via CD3zeta and costimulatory domains
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06652633
disease_id_num_tar_ref
2688
drug_id_num_tar_ref
7167