gene_symbol
ITGB2
hgnc_id
HGNC:6155
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ATG antibodies bind CD18 (LFA-1 beta) on T cells and trigger complement-dependent lysis and Fc-mediated ADCC/phagocytosis, depleting those cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
adhesion molecule
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06378060
disease_id_num_tar_ref
2749
drug_id_num_tar_ref
7328