gene_symbol
TNFRSF17
hgnc_id
HGNC:11913
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The BCMA×CD3 bispecific engages T cells via CD3 and binds BCMA on target cells, forming an immune synapse and activating T-cell cytotoxicity (perforin/granzyme-mediated lysis) against BCMA-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Bivalent BCMA binding in 2+1 bispecific format
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06121843
disease_id_num_tar_ref
2771
drug_id_num_tar_ref
7398