gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Alnuctamab binds CD3 on T cells to engage and activate them against BCMA+ tumor cells; T cells kill BCMA-expressing cells via immune synapse formation and perforin/granzyme release. CD3+ cells are not targeted for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Monovalent CD3 binding in 2+1 bispecific format
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06121843
disease_id_num_tar_ref
2771
drug_id_num_tar_ref
7398