gene_symbol
DLL3
hgnc_id
HGNC:2909
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The bispecific antibody binds DLL3 on tumor cells and blocks CD47, removing the “don’t‑eat‑me” signal and engaging Fcγ receptors to trigger macrophage-mediated phagocytosis (ADCP) and NK cell ADCC, killing DLL3+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Notch ligand on neuroendocrine tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05652686
disease_id_num_tar_ref
2785
drug_id_num_tar_ref
7432