gene_symbol
CD47
hgnc_id
HGNC:1682
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CD47 is blocked to remove the SIRPα 'don't-eat-me' signal, enhancing ADCP/ADCC against DLL3-positive tumor cells; CD47-expressing cells themselves are not directly targeted for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Macrophage checkpoint receptor; blockade disrupts CD47–SIRPα 'don't-eat-me' signal
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05652686
disease_id_num_tar_ref
2785
drug_id_num_tar_ref
7432