gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Pertuzumab binds HER2 on target cells and its Fc engages Fcγ receptor–bearing immune cells (e.g., NK cells) to trigger ADCC; blockade of HER2 dimerization/signaling can also induce apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular dimerization domain (subdomain II); blocks HER2/HER3 and HER2/EGFR heterodimerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05891561
disease_id_num_tar_ref
2787
drug_id_num_tar_ref
7441