gene_symbol
WT1
hgnc_id
HGNC:12796
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
WT1 mRNA–loaded dendritic cells prime WT1-specific CD8+ T cells, which recognize WT1 peptides on MHC I of target cells and kill them via perforin/granzyme-mediated cytotoxicity (with CD4+ T-cell help).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Presented as multiple WT1-derived peptides on MHC class I and II by autologous dendritic cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05765084
disease_id_num_tar_ref
2790
drug_id_num_tar_ref
7449