gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds HER2, is internalized, and releases the cytotoxic payload MMAE, which disrupts microtubules leading to G2/M arrest and apoptosis; released MMAE can also cause bystander killing of nearby cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC antibody target on tumor cell surface
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06063018
disease_id_num_tar_ref
2796
drug_id_num_tar_ref
7467