gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The mRNA expresses a CD19×CD3 bispecific that binds CD3ε on T cells to recruit/activate them against CD19+ B cells; T cells (CD3ε+) are not killed, they mediate killing of CD19+ targets via cytotoxic synapse and perforin–granzyme release.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
T-cell receptor/CD3 complex subunit
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06747156
disease_id_num_tar_ref
2805
drug_id_num_tar_ref
7493