gene_symbol
CLDN18
hgnc_id
HGNC:2039
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TAC T cells bind CLDN18.2 on target cells and engage endogenous TCR/CD3, activating CTL effector functions (perforin/granzyme and Fas–FasL) to kill CLDN18.2-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
A2 isoform of claudin-18; extracellular domain on tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05862324
disease_id_num_tar_ref
2869
drug_id_num_tar_ref
7674