gene_symbol
TNFRSF4
hgnc_id
HGNC:11918
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds OX40 on activated T cells and, via its afucosylated IgG1 Fc, engages FcγRIIIa on NK cells to trigger ADCC, directly depleting OX40+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocks OX40–OX40L interaction; afucosylated IgG1 with enhanced ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06214481
disease_id_num_tar_ref
2901
drug_id_num_tar_ref
7764