gene_symbol
KLRK1
hgnc_id
HGNC:18788
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The orthogonal NKG2D on ASP2802 CAR T cells serves as a docking receptor. MA-20 bridges CD20 on tumor cells to this receptor, activating CAR T cells to kill CD20+ targets via perforin/granzyme cytolysis; NKG2D-expressing CAR T cells are not killed.
enzyme_product
Off
epitope
Off
variant
On
isoform
Off
hla_specific
Off
gated
On
other_modifier
Engineered, orthogonal NKG2D receptor engaged by MA-20’s non-native NKG2D ligand to activate convertibleCAR-T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06248086
disease_id_num_tar_ref
21
drug_id_num_tar_ref
51