gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti‑EGFR antibody binds EGFR on target cells and its Fc engages FcγRIIIa (CD16) on NK cells to trigger ADCC, killing EGFR+ cells; complement activation and phagocytosis may also contribute, while signaling blockade is mainly cytostatic.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain; blocks ligand binding and receptor dimerization; glycoengineering enhances ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06542588
disease_id_num_tar_ref
259
drug_id_num_tar_ref
724