gene_symbol
CD44
hgnc_id
HGNC:1681
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
A Lu-177–labeled anti-CD44v6 antibody binds CD44v6 and delivers beta radiation to the bound cell, causing DNA double-strand breaks and cell death; cross-fire can also kill nearby cells.
enzyme_product
Off
epitope
On
variant
On
isoform
On
hla_specific
Off
gated
Off
other_modifier
Exon v6-containing CD44 isoform; v6-specific extracellular epitope
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06639191
disease_id_num_tar_ref
3023
drug_id_num_tar_ref
8113