gene_symbol
WT1
hgnc_id
HGNC:12796
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Dendritic-cell vaccination presents WT1 peptides and trans-presents IL-15 to prime/expand WT1-specific CD8+ T cells and activate NK cells. These effectors recognize WT1 peptide–MHC on tumor cells and kill them via perforin/granzyme (and Fas/FasL) pathways.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Presented by MHC class I/II on autologous dendritic cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05964361
disease_id_num_tar_ref
3075
drug_id_num_tar_ref
8242