gene_symbol
IL15
hgnc_id
HGNC:5977
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
IL-15 is used as a stimulatory signal (transpresented by the vaccine DCs) to expand/activate CD8+ T and NK cells; these effectors kill WT1-expressing tumor cells via perforin/granzyme-mediated cytotoxicity, not IL-15–expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Transpresented bound to IL-15 receptor alpha (IL15RA) on DC surface
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05964361
disease_id_num_tar_ref
3075
drug_id_num_tar_ref
8242