gene_symbol
IL2RG
hgnc_id
HGNC:6010
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The vaccine trans-presents IL-15/IL-15Ralpha to CD132/CD122 on T and NK cells, activating and expanding them; these effectors then kill WT1-expressing tumor cells via CTL and NK cytotoxicity. CD132+ cells are not targeted for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Receptor engaged with IL2RB by transpresented IL-15 on T and NK cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05964361
disease_id_num_tar_ref
3075
drug_id_num_tar_ref
8242