gene_symbol
CDH6
hgnc_id
HGNC:1765
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CDH6 antibody–drug conjugate binds CDH6 on tumor cells, internalizes, and releases a DXd topoisomerase I inhibitor that induces DNA damage (single-strand breaks), causing cell-cycle arrest and apoptosis, with potential bystander killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface adhesion protein; ADC binding triggers internalization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06161025
disease_id_num_tar_ref
3121
drug_id_num_tar_ref
8378