gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC targets CDH6 on cell surfaces, is internalized, and releases deruxtecan to inhibit TOP1, causing DNA damage and apoptosis; TOP1 expression alone does not determine killing.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
DXd payload inhibits TOP1, causing DNA damage
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06161025
disease_id_num_tar_ref
3121
drug_id_num_tar_ref
8378