gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds TROP2 (not topoisomerase I); after TROP2-mediated internalization it releases a camptothecin topoisomerase I inhibitor that causes DNA damage and apoptosis, with possible bystander effect. Cells are not killed due to topoisomerase I expression itself.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC payload (camptothecin-derived TOP1 inhibitor)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06305754
disease_id_num_tar_ref
3170
drug_id_num_tar_ref
8506