gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The IgG1 anti-EGFR antibody opsonizes EGFR+ cells and engages Fcγ receptors on NK cells/macrophages to induce ADCC (and possibly complement-mediated lysis). EGFR signaling blockade is mainly cytostatic/radiosensitizing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
HER1/ERBB1; receptor tyrosine kinase; extracellular domain
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05831930
disease_id_num_tar_ref
3230
drug_id_num_tar_ref
8662