gene_symbol
PTPRC
hgnc_id
HGNC:9666
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
rATG contains antibodies that bind CD45 on lymphocytes and trigger complement-dependent cytotoxicity and Fc-mediated ADCC, leading to lysis/apoptosis of CD45+ cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Multiple isoforms (CD45RA/RO) may be recognized
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05806749
disease_id_num_tar_ref
3274
drug_id_num_tar_ref
8793