gene_symbol
ITGB2
hgnc_id
HGNC:6155
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Polyclonal IgG binds CD18 on leukocytes/T cells and induces complement-dependent lysis and Fc-mediated ADCC, with additional apoptosis, depleting the target-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Component of LFA-1 integrin (with ITGAL)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05806749
disease_id_num_tar_ref
3274
drug_id_num_tar_ref
8793