gene_symbol
TNFRSF4
hgnc_id
HGNC:11918
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
After binding OX40 on activated T cells, the IgG1 Fc engages effector mechanisms (ADCC/ADCP and possibly complement), leading to depletion/lysis of OX40+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Receptor; blocks OX40–OX40L costimulation
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05891119
disease_id_num_tar_ref
3326
drug_id_num_tar_ref
8959