gene_symbol
ESR1
hgnc_id
HGNC:3467
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The DC1 vaccine presents ESR1 peptides on MHC I/II and secretes IL-12 to prime ESR1-specific CD8+ and Th1 responses. Activated CTLs then recognize ESR1 peptide–MHC on tumor cells and kill them via perforin/granzyme and Fas–FasL pathways.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Presented via MHC class I/II by DC1 cells to prime T-cell responses
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06691035
disease_id_num_tar_ref
3343
drug_id_num_tar_ref
9011