gene_symbol
ESR1
hgnc_id
HGNC:3467
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Vaccine-primed ESR1-specific CD8+ T cells recognize mutant ESR1 peptide–MHC I on tumor cells and kill them via perforin/granzyme (and Fas/FasL) after Th1 polarization by IL-12–producing dendritic cells.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Patient-specific mutated ESR1 epitopes; presented via MHC class I/II by DC1 cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06691035
disease_id_num_tar_ref
3343
drug_id_num_tar_ref
9011