gene_symbol
CTLA4
hgnc_id
HGNC:2505
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
IgG1 anti-CTLA-4 engages Fcγ receptors on NK cells/macrophages to deplete CTLA-4–high Tregs via ADCC/ADCP, killing CTLA-4–expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Also known as CD152; antibody blocks CTLA-4 interaction with CD80/CD86; IgG1 Fc may enable Treg depletion
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05653180
disease_id_num_tar_ref
3370
drug_id_num_tar_ref
9101