gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The DC vaccine primes and expands EBV-specific T cells; these T cells recognize EBV peptides presented on HLA (including class II) and kill EBV+ cells via perforin/granzyme and Fas–FasL pathways. The vaccine itself does not directly kill cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Presented on HLA-DR/DP/DQ by autologous dendritic cells to CD4+ T cells (peptide–MHC II complexes)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05635591
disease_id_num_tar_ref
3423
drug_id_num_tar_ref
9248