gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD20 mAb depletes CD20+ B cells via enhanced Fc-mediated ADCC/ADCP (NK cells, macrophages), direct non-apoptotic cell death (type II), and some complement-dependent cytotoxicity.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type II anti-CD20 epitope; glycoengineered Fc enhances Fc-gamma RIIIa (CD16A)-mediated ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06108232
disease_id_num_tar_ref
3429
drug_id_num_tar_ref
9266