gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
AZD0901 binds CLDN18.2 (not tubulin), is internalized, and releases MMAE that disrupts tubulin/microtubules to cause mitotic arrest and apoptosis; Fc-mediated ADCC may also contribute.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
vinca-binding site (MMAE payload)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06346392
disease_id_num_tar_ref
3431
drug_id_num_tar_ref
9269