gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Antibody-drug conjugate binds HER2 on target cells, is internalized, and releases MMAE intracellularly, disrupting microtubules to cause mitotic arrest and apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC antibody target
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06420973
disease_id_num_tar_ref
292
drug_id_num_tar_ref
825