gene_symbol
FCGRT
hgnc_id
HGNC:3621
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
No killing via FcRn. The LS-modified Fc binds FcRn in endosomes to enhance recycling and half-life; cytotoxic functions (neutralization, ADCC/CDC) act against HIV-1 Env on virions/infected cells, not FcRn-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
LS (M428L/N434S) mutation increases FcRn affinity at acidic pH to extend half-life
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05769569
disease_id_num_tar_ref
3531
drug_id_num_tar_ref
9565