gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR T cells recognize the target antigen via the CAR and, upon CD3ζ/costimulatory signaling, directly kill antigen-positive cells through perforin–granzyme release and Fas–FasL–mediated apoptosis (with cytokine-mediated effects).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Antigen varies by parent trials (NCT05660369, NCT06026319); MHC-independent CAR binding to surface antigen on malignant cells.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05024175
disease_id_num_tar_ref
3574
drug_id_num_tar_ref
9691