gene_symbol
ITGB6
hgnc_id
HGNC:6161
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds integrin αvβ6 on target cells, is internalized, and releases MMAE via a cleavable linker; MMAE inhibits tubulin polymerization, causing G2/M arrest and apoptosis (with potential bystander killing).
enzyme_product
Off
epitope
On
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
Heterodimer-specific binding to αvβ6 integrin
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06012435
disease_id_num_tar_ref
3653
drug_id_num_tar_ref
9917