gene_symbol
TNFSF7
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CD70-directed CAR-NK cells bind CD70 on target cells, activating NK degranulation (perforin/granzymes) and death-receptor pathways to lyse/apoptose CD70+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface TNF ligand (TNFSF7) overexpressed on TCL/AML; primary CAR antigen
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06696846
disease_id_num_tar_ref
3827
drug_id_num_tar_ref
10322