gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti-TROP2 antibody–drug conjugate binds TROP2, is internalized, and releases a topoisomerase I inhibitor payload that induces DNA damage and apoptosis in the target cell.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface glycoprotein; antibody component binds and is internalized (ADC)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06074588
disease_id_num_tar_ref
3869
drug_id_num_tar_ref
10444