gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds TROP2 on tumor cells, is internalized, and releases a topoisomerase I–inhibitor payload that inhibits DNA topoisomerase I, causing DNA damage and tumor cell death.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Intracellular target of released ADC payload (topoisomerase I inhibitor)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06074588
disease_id_num_tar_ref
3869
drug_id_num_tar_ref
10444