gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ATG antibodies bind CD3 on T cells and deplete them via complement-dependent cytotoxicity, Fc receptor–mediated ADCC/ADCP, and apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CD3 complex target; CD3E provided as representative subunit
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04291703
disease_id_num_tar_ref
3870
drug_id_num_tar_ref
10447