gene_symbol
CD8A
hgnc_id
HGNC:1706
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ATG antibodies bind CD8 on T cells and induce depletion via complement-dependent lysis, Fc receptor–mediated ADCC/phagocytosis, and apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CD8 co-receptor; CD8A provided as representative subunit
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04291703
disease_id_num_tar_ref
3870
drug_id_num_tar_ref
10447