gene_symbol
TNF
hgnc_id
HGNC:11892
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds transmembrane TNF-alpha on cells; Fc region triggers ADCC/CDC via FcγR+ effectors and complement, and can induce apoptosis via reverse signaling in tmTNF-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds both soluble and transmembrane TNF-alpha; neutralizes TNF signaling and can trigger Fc-mediated effector functions.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06075706
disease_id_num_tar_ref
3897
drug_id_num_tar_ref
10514