gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR-T cells recognize the tumor antigen peptide–HLA class I complex and, upon TCR engagement, directly kill target cells via perforin/granzyme-mediated cytolysis and death receptor pathways.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Specific peptide epitope and restricting HLA allele vary by the engineered TCR construct/parent trial.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05713214
disease_id_num_tar_ref
3931
drug_id_num_tar_ref
10620