gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds TROP2 on tumor cells, is internalized, and releases a topoisomerase I inhibitor payload that causes DNA damage and apoptotic cell death (with possible bystander effect).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC antibody antigen; cell-surface target for internalization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05816252
disease_id_num_tar_ref
3934
drug_id_num_tar_ref
10628