gene_symbol
PVRL4
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
BT8009 binds Nectin-4 on tumor cells, is internalized, and releases MMAE, a microtubule inhibitor, causing mitotic arrest and apoptosis of Nectin-4–expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface adhesion molecule targeted by Bicycle toxin conjugate
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06225596
disease_id_num_tar_ref
3965
drug_id_num_tar_ref
10701