gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC targets CD79b on B cells, is internalized, and releases a payload that binds β-tubulin (vinca site) to disrupt microtubules and induce apoptosis; β-tubulin expression is not the basis of target cell selection.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Intracellular payload target (e.g., MMAE) that inhibits microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06008691
disease_id_num_tar_ref
3990
drug_id_num_tar_ref
10769