gene_symbol
TLR4
hgnc_id
HGNC:11850
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
HSP70 in the vaccine activates TLR4 on antigen‑presenting cells to enhance cross‑presentation, generating HPV16 E7‑specific CTLs that kill E7+ tumor cells; TLR4-expressing cells are not targeted or killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
HSP70 can act as a DAMP to activate dendritic cells via TLR4 signaling
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06508138
disease_id_num_tar_ref
4086
drug_id_num_tar_ref
11025