gene_symbol
TLR2
hgnc_id
HGNC:11848
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The DNA vaccine secretes HPV16 E7-HSP70 to activate APCs and prime E7-specific CD8+ T cells; these CTLs kill HPV16 E7-expressing cells via perforin/granzyme. TLR2-expressing cells are not targeted for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
HSP70 can engage TLR2 to promote innate activation and maturation of antigen-presenting cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06508138
disease_id_num_tar_ref
4086
drug_id_num_tar_ref
11025