gene_symbol
IL5RA
hgnc_id
HGNC:6017
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Benralizumab binds IL-5Rα on eosinophils/basophils and, via its afucosylated Fc, engages FcγRIIIa on NK cells to induce strong ADCC, depleting IL-5Rα-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocks IL-5 signaling on eosinophils/basophils
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05692180
disease_id_num_tar_ref
4099
drug_id_num_tar_ref
11061