gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Benralizumab binds IL-5Rα on eosinophils and uses its Fc to engage CD16a on NK cells, triggering ADCC that kills IL-5Rα+ eosinophils. CD16a-expressing cells (NK cells) are engaged as effectors, not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-dependent engagement on NK cells to trigger ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05692180
disease_id_num_tar_ref
4099
drug_id_num_tar_ref
11061