gene_symbol
CD70
hgnc_id
HGNC:11937
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CD70-directed CAR T cells bind CD70 on target cells, triggering T-cell activation and immune synapse formation, leading to perforin/granzyme-mediated cytolysis (and related T-cell effector mechanisms).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
TNFSF7; tumor-associated antigen and ligand for CD27 on the tumor cell surface
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05795595
disease_id_num_tar_ref
4150
drug_id_num_tar_ref
11215